Immunotherapy of Type I Diabetes
نویسندگان
چکیده
منابع مشابه
Immunotherapy of type I diabetes.
A recent NIH panel in which I participated unanimously agreed that wide clinical application of immunotherapy for type I diabetes is at present inappropriate. The risks of premature application of such therapy outweigh potential benefits. In this editorial, I will briefly review the current information upon which I and my colleagues have begun small research trials of immunotherapy which 1 beli...
متن کاملType 1 Diabetes Immunological Tolerance and Immunotherapy
1 Immunology Unit, Pathology & Clinical Laboratory Medicine, King Fahad Medical City, Box 59046, Riyadh 11525, Saudi Arabia 2Laboratory of Immunoendocrinology, Institute of Pathology CHU-B23, University of Liege Center of Immunology (CIL), 4000 Liege-Sart Tilman, Belgium 3Department of Pathology and Immunology, Diabetes Institute, Rangos Research Center, University of Pittsburgh School of Medic...
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Type 1 diabetes mellitus (T1D), also known as insulin dependent diabetes mellitus, is a chronic immune mediated disease that is characterized by selective loss of insulin producing β cells of the pancreatic islets in genetically susceptible subjects . The majority (95%) of cases are attributable to an autoimmune-mediated destruction of β cells (type 1a) while a small minority (5%) of cases resu...
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The nonobese diabetic (NOD) mouse is a well-recognised animal model of spontaneous autoimmune insulin-dependent diabetes mellitus. The disease is T-cell mediated, involving both CD4 and CD8 cells. Its progress is controlled by a variety of regulatory T cells. An unprecedented number of immunological treatments have been assessed in this mouse strain. This chapter systematically reviews most of ...
متن کاملImmunotherapy for the Prevention and Treatment of Type 1 Diabetes
In the past 15 years, multiple clinical trials have attempted to find prevention for type 1 diabetes. The accompanying article by Bresson and von Herrath (1) reviews basic mechanisms underlying immunoprevention and immunotherapy of type 1 diabetes as well as selected human trials in the context of data from animal models. The second part of this minisymposium provides an overview of the recent ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 1983
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.6.5.521